Liver Disease

Fatty Liver Disorder

Low-carbohydrate diet induced reduction of hepatic lipid content observed with a rapid non-invasive MRI technique K G Hollingsworth, PhD 1 M Z Abubacker, FRCR 1 I Joubert 1 M E D Allison, FRCP 2 and D J Lomas, FRCR 1

Rapid reduction in the amount of fat in the liver (i.e., from non-alcoholic fatty liver disorder) are noted in this short term study of overweight and obese patients:

Low carbohydrate diets are currently fashionable for inducing weight loss, but the metabolic effects at organ level are not well understood, especially the effect on liver fat storage. Such studies require serial hepatic fat measurements, for which liver biopsy is impractical. In 10 healthy volunteers we demonstrate the use of rapid (total 2 min acquisition time, 10 min magnet room time), non-invasive, quantitative MRI to serially measure hepatic fat changes induced by following a low carbohydrate diet for 10 days. A significant (p<0.01) reduction in hepatic fat after 3 days of dieting was observed in 5 subjects. All subjects demonstrated significant (p<0.01) reductions in hepatic fat by day 10. A strong correlation ({kappa} = 0.81) existed between the initial fat content and the percentage fat content reduction in the first 3 days of the diet.

Chronicling the End of the Low Fat Craze