Research on the effect of carbohydrates on triglyceride levels:

Effect of Dietary Carbohydrate on Triglyceride Metabolism in Humans1 (202kb PDF File), Elizabeth J. Parks, Department of Food Science and Nutrition, University of Minnesota, Twin Cities, St. Paul, MN 55108-6099

ABSTRACT When the content of dietary carbohydrate is elevated above the level typically consumed (.55% of
energy), blood concentrations of triglycerides rise. This phenomenon, known as carbohydrate-induced hypertriglyceridemia, is paradoxical because the increase in dietary carbohydrate usually comes at the expense of dietary fat. Thus, when the content of the carbohydrate in the diet is increased, fat in the diet is reduced, but the content of fat (triglycerides) in the blood rises. The present article will review studies of carbohydrate-induced hypertriglyceridemia, highlighting data obtained in fasted subjects habituated to high carbohydrate diets, data obtained from subjects in the fed state, and metabolic studies investigating fatty acid and triglyceride synthesis in subjects consuming diets of different carbohydrate content. The available data have been recently expanded by new methodologies, such as the use of stable isotopes, to investigate the metabolism of sugars in humans in vivo. Given the significant increase in body weight observed in the American population over the past decade and the changing availability of carbohydrate in the food supply, future studies of carbohydrate-induced hypertriglyceridemia promise to provide important information of how the macronutrient composition of the diet can influence health. J. Nutr. 131: 2772S–2774S, 2001.

Carbohydrate-Induced Hypertriglyceridemia: An Insight into the Link between Plasma Insulin and Triglyceride Concentrations (141KB PDF File), T. MCLAUGHLIN, F. ABBASI, C. LAMENDOLA, H. YENI-KOMSHIAN, AND
G. REAVEN, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305

This study was initiated to test the hypothesis that endogenous hypertriglyceridemia results from a defect in the ability of insulin to inhibit the release of very low-density lipoprotein-triglyceride (TG) from the liver. To accomplish this goal, plasma glucose, insulin, free fatty acid (FFA), and TG concentrations were compared in 12 healthy volunteers, in response to diets containing either 40% or 60% of total calories as carbohydrate (CHO). The protein content of the two diets was similar (15% of calories), and the fat content varied inversely with the amount ofCHO(45% or 25%). The diets were consumed in random order, and measurements were made of plasma glucose, insulin, FFA, and TG concentrations at the end of each dietary period, fasting, and at hourly intervals following breakfast and lunch. The results indicated that the 60% CHO diet resulted in higher fasting plasma TG concentrations associated with higher day-long plasma insulin and TG concentrations, and lower FFA concentrations. These results do not support the view that hypertriglyceridemia is secondary to a failure of insulin to inhibit hepatic TG secretion. (J Clin Endocrinol Metab 85: 3085–3088, 2000)

Effect of High-Carbohydrate Feeding on Trigylceride and Saturated Fatty Acid Synthesis, (706KB PDF File), Lisa C. Hudgins, The Rogosin Institute, Rockefeller University, New York, New York, 10021

[Abstract not available – click link for PDF file with abstract]

Chronicling the End of the Low Fat Craze